Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Carcinoma | D002277 | — | C80.0 | 2 | 1 | 3 | — | — | 6 |
Hepatocellular carcinoma | D006528 | — | C22.0 | 2 | 1 | 3 | — | — | 6 |
Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 2 | — | 4 | — | — | 6 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Colorectal neoplasms | D015179 | — | — | 2 | 2 | — | — | — | 3 |
Adenocarcinoma | D000230 | — | — | — | 1 | — | — | — | 1 |
Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | 1 | — | — | — | 1 |
Non-small-cell lung carcinoma | D002289 | — | — | — | 1 | — | — | — | 1 |
Sarcoma | D012509 | — | — | — | 1 | — | — | — | 1 |
Transitional cell carcinoma | D002295 | — | — | — | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Neoplasms | D009369 | — | C80 | 6 | — | — | — | — | 6 |
Gastrointestinal neoplasms | D005770 | — | C26.9 | 2 | — | — | — | — | 2 |
Intestinal neoplasms | D007414 | — | C26.0 | 1 | — | — | — | — | 1 |
Digestive system neoplasms | D004067 | — | — | 1 | — | — | — | — | 1 |
Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | — | — | — | — | 1 |
Drug common name | Brivanib alaninate |
INN | brivanib alaninate |
Description | Brivanib alaninate is a carboxylic ester resulting from the formal condensation of the carboxy group of L-alanine with the hydroxy group of brivanib. It is a prodrug of brivanib (BMS-540215), a potent oral dual inhibitor of VEGFR-2 and FGFR-1 (IC50 of 25 nM and 148 nM, respectively) and was in development for the treatment of hepatocellular and colon carcinomas. It has a role as an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, a prodrug, an apoptosis inducer, a fibroblast growth factor receptor antagonist and an angiogenesis inhibitor. It is a pyrrolotriazine, an aromatic ether, a fluoroindole, a diether, a carboxylic ester and a L-alanine derivative. It is functionally related to a brivanib. |
Classification | Small molecule |
Drug class | angiogenesis inhibitors |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | Cc1cc2c(F)c(Oc3ncnn4cc(OC[C@@H](C)OC(=O)[C@H](C)N)c(C)c34)ccc2[nH]1 |
PDB | — |
CAS-ID | 649735-63-7 |
RxCUI | — |
ChEMBL ID | CHEMBL270995 |
ChEBI ID | — |
PubChem CID | 11154925 |
DrugBank | DB11865 |
UNII ID | U2Y5OFN795 (ChemIDplus, GSRS) |